Clinical reference · HPH-000
HPH ward cards on sildenafil, tadalafil, vardenafil, and eight systemic drugs. Mechanism, PK, trials. We do not sell tablets.
Four shelves. Jump to the molecule you need — each guide carries a stable HPH code for citations.
Same cGMP pathway, different half-lives. Meal timing and side-effect texture vary more than most patients expect.
Wakefulness, neuropathic pain, spasticity — three mechanisms, three monitoring plans. Don't treat them as interchangeable.
Outpatient beta-lactams, antiparasitics, and a peripheral prokinetic with a regulatory gap in the U.S.
Loop diuretic kinetics in decompensated heart failure. Oral steroid tapers residents still botch.
For questions bigger than one tablet strength.
Why PDE5 drugs need arousal, why nitrates stay off the table, and where vascular comorbidity fits.
Read topic HPH-004ANDA bioequivalence, Orange Book AB ratings, and why Kamagra/Cenforce aren't U.S. generics.
Read topicWard rounds don't pause for 30-page prescribing information. We strip each label down to what you'd look up mid-shift: mechanism, half-life, the pivotal trial endpoint, dose ceiling, and the boxed warning that changes your order.
No pharma money. Viagra and Provigil show up only so you know which molecule we mean — not as a recommendation.
Pharmacy students, residents, pharmacists, anyone who prescribes these enough to need a refresher but not enough to carry the PI in their head.
Start with the live FDA label — doses, boxed warnings, PK tables — then pull the registration trials it cites. ADME grids and timelines only when they'd save you from doing the math on a napkin.
Off-label use overseas gets a line when it matters. Domperidone is the obvious one: dispensed in plenty of countries, not approved here.
FDA posts a label supplement tomorrow? The PDF wins. These pages are a map, not the contract.
Drug guides run intro → mechanism → PK → trials → dosing → interactions → adverse effects → special populations → bottom line. HPH-004 and HPH-005 handle class questions — generics, pathway — instead of one tablet strength.
Cite the HPH code in coursework. Related links at the bottom are suggested reading, not prescribing advice.
Drugs under /medications/. Class topics under /health-topics/. Legal under /legal/.
Long guides use a horizontal section jump bar — not the sidebar TOC some other reference sites use.
| Drug | Brand | t½ (approx.) | Food | HPH |
|---|---|---|---|---|
| Sildenafil | Viagra | 4 h | High-fat ↓ Cmax | 001 |
| Tadalafil | Cialis | 17.5 h | Minimal | 002 |
| Vardenafil | Levitra | 4–5 h | High-fat ↓ Cmax | 003 |
| Modafinil | Provigil | 12–15 h | Minor delay | 006 |
| Gabapentin | Neurontin | 5–7 h | None meaningful | 011 |
| Furosemide | Lasix | 1–2 h | None | 008 |
ED block: HPH-005 pathway first, then any of HPH-001–003, finish with HPH-004 on generics.
Sleep week: HPH-006. ID block: HPH-009 then HPH-013.
Eleven drug guides, two class topics. PDE5 drugs for ED. Modafinil, gabapentin, tizanidine for CNS and spasticity. Domperidone with its U.S. regulatory hole spelled out. Furosemide, amoxicillin, prednisolone, ivermectin for the rest of outpatient practice.
Every file gets an HPH code. Footer links cluster related science — that's reading order, not a swap chart.
| HPH ID | Guide | Type |
|---|---|---|
| HPH-001 | Sildenafil | Drug |
| HPH-002 | Tadalafil | Drug |
| HPH-003 | Vardenafil | Drug |
| HPH-004 | PDE5 generics (FDA) | Topic |
| HPH-005 | ED pathway | Topic |
| HPH-006 | Modafinil | Drug |
| HPH-007 | Domperidone | Drug |
| HPH-008 | Furosemide | Drug |
| HPH-009 | Amoxicillin | Drug |
| HPH-010 | Tizanidine | Drug |
| HPH-011 | Gabapentin | Drug |
| HPH-012 | Prednisolone | Drug |
| HPH-013 | Ivermectin | Drug |
Short cross-links — full PK lives in each HPH guide.
Oral PDE5 drugs are still first-line for ED where they're approved. Same cGMP pathway; different half-lives, different meal sensitivity.
Students memorize IC50 rankings like they're board questions. Labeled doses converge for most men anyway — exposure and protein binding matter as much as potency on a slide.
Nitrates stay contraindicated for the whole class. A 17-hour half-life doesn't make that negotiation easier.
Modafinil keeps people awake without full amphetamine signaling at usual doses. Mechanism is still messy — DAT inhibition, hypothalamic circuits, pick your favorite paper.
Gabapentin and tizanidine land in the same clinic notes but share almost nothing pharmacologically. Alpha-2-delta binding vs central alpha-2 agonism. Renal dose adjustment vs CYP1A2 traps.
Amoxicillin still works PO when the bug cooperates. Time above MIC drives killing — not peak height.
Ivermectin dosing shifts by indication; scabies is weight-based. Veterinary paste is a concentration gamble nobody should take.
Furosemide oral absorption falls apart in bad heart failure. Prednisolone tapers after long courses — HPA suppression isn't a lecture slide, it's real.
Motilium is familiar globally and missing from U.S. FDA approval. Peripheral D2 blockade, QT risk, azole interactions — all still apply wherever it's dispensed.
Health Pharmacology is a reference shelf, not a marketing site. We track mechanisms and numbers — not which manufacturer paid for the banner ad.
HPH codes stay fixed when facts update. Your citations shouldn't break because we fixed a half-life.
We refresh numbers when labels change. HPH IDs stay put.
No ads. No affiliate checkout. No 'ask your doctor about Brand X' copy.
We cite the trials behind approval — IIEF for PDE5, MWT for modafinil, Ashworth for tizanidine. Placebo response in ED studies is massive; skip it and the numbers lie prettier than clinic feels.
Domperidone gets used in many countries and isn't FDA-approved here. We say that upfront. QT risk with macrolides and azoles still applies wherever it's sold.
HPH-001 through HPH-013 — stable IDs for syllabi, slide decks, and citations that won't rot.
Close the offer that will sell sildenafil without a prescription. A lawful fill in the United States needs a valid prescription and a pharmacy licensed in the U…
Get a prescription before you look for tadalafil online. In the United States the tablet is still a prescription drug: a clinician has to order it, and a pharma…
Buying vardenafil online in the United States means a prescription a clinician has written and a pharmacy licensed in the state where the medicine will be dispe…
“Buy modafinil online” in U.S. search results mixes three different offers: a real telehealth or clinic prescription filled by a state-licensed pharmacy, a pric…
You cannot buy Motilium — the international brand name for domperidone — from a routine U.S. pharmacy shelf the way you buy an FDA-approved tablet. Domperidone …
You can buy furosemide (brand name Lasix) online in the United States only with a prescription and from a state-licensed pharmacy. The same active drug ships as…
A lawful US online order for amoxicillin still needs a clinician’s prescription and a pharmacy licensed in the state where the medicine will be dispensed. Amoxi…
Buying tizanidine online in the United States means a prescription a clinician has written and a named pharmacy licensed in the state that will dispense it. Zan…
Buying gabapentin online in the United States means a prescription a clinician has written and a pharmacy licensed in the state where the medicine will be dispe…
A prednisone offer is not a prednisolone fill. Prednisone is a biologically inactive prodrug: hepatic 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) has…
If the listing will not name the pharmacy, do not buy ivermectin online from it. In the United States the human tablet is a prescription antiparasitic: a clinic…
“Generic Viagra online” and “buy generic sildenafil online” usually mean one of two objects that look alike in a search result and are not the same in regulatio…
Buying ED pills online in the United States is still a prescription path, not a cart that invents an erection. The oral medicines people mean — sildenafil (Viag…
We don't sell drugs and we don't take sponsorship. Names identify molecules.
Check the live label. Talk to the patient's clinician before you change anything.
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